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KMID : 0378020090520050028
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New Medical Journal
2009 Volume.52 No. 5 p.28 ~ p.31
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Interaction Between Mivacurium and Nicardipine
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Kim Tae-Kwan
Han In-Soo
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Abstract
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Background: During venous injection of nicardipine, the neuromuscular blocking effects of nondepolarizing neuromuscular blocker (NDNM) were prolonged and potentiated. We investigated the influence of the nicardipine venous injection on mivacurium induced neuromuscular blockade.
Method: We studied 58 adult anesthetized patients, ASA physical status I or II, between 18 and 63 years old. Neuromuscular monitoring was measured by TOF-GUARD? (Biometer CO., Denmark). The induction of anesthesia in patients was done by thiopental sodium 3-5 mg/kg , and maintained with 2 L/min N2O, 2 L/min O2 and 1.5 vol% sevoflurane. Patients were randomly assigned to 2 groups: 1) Control group (mivacurium 0.16 mg/kg), 2) NIC group (mivacurium 0.16 mg/kg + nicardipine 1.0 mg). We measured the train-of-four (TOF) response from the beginning of recovery to the complete regaining of muscle twitch.
Results: Nicardipine prolonged the mivacurium action duration. T1(control group: 11.6 ±0.1 min, NIC group: 15.9±0.2 min), T25 (control group 14.9±0.7 min, NIC group 20.5 ±0.4 min), T75(control group 20.5±0.7 min, NIC group 29.5±0.4 min), T95(control group: 25.6±1.1 min, NIC group 39.8±0.5 min) and recovery index (control group 5.6±0.7 min, NIC group 9.0±0.4 min) were significantly prolonged in NIC group (p<0.05) (Table3).
Conclusion: Theses results suggest that venous injection of nicardipine prolonged the neuromuscular blocking effect of mivacurium.
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KEYWORD
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Interactions, Drug: mivacurium, nicardipine. Monitoring: train-of-four, Neuromuscular relaxants: mivacurium
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